ABSTRACT
Background: The aim of the research was to study the biochemical profile of the male patients diagnosed with alcohol dependence syndrome and its correlation with the severity of dependence. Methodology: A descriptive study comprising of 60 patients admitted in the psychiatry de-addiction clinic at HSK hospital from 1st July 2017 to 31st December 2017 was done after taking institutional ethical committee clearance. A semi-structured proforma was used to determine the socio-demographic details like education, occupation, socio-economic status etc. the severity of dependence was determined using Severity of Alcohol Dependence Questionnaire (SADQ) scale and basic biochemical tests were performed. Descriptive analysis using an appropriate statistical test was done. Results: The mean age at presentation was 37.9 years. Out of 60 patients, 21 (35%) had mild dependence, 24 (40%) had moderate dependence and 15 (25%) had severe dependence. Hepatic enzymes AST and ALT were raised in 76.67% and 66.67% patients respectively. AST to ALT ratio was above 2 in 11.67% patients. There was a significant correlation between total SADQ scores and Alanine Transaminase (? = 0.281, P = 0.03, n = 60). Conclusion: The biochemical tests were deranged in most of the patients with alcohol dependence. Certain markers can be developed based on their significant association with the dependence levels, thus, helping in early diagnosis and prevention of alcohol dependence syndrome